Cancer Hazard * Lindane may be a
CARCINOGEN in humans since it has been shown to cause liver, lung, endocrine
glands and other types of cancer in animals. * There is limited evidence that
Lindane is associated with leukemia in humans. * Many scientists believe there
is no safe level of exposure to a carcinogen. Such substances may also have the
potential for causing reproductive damage in humans. 1988
http://chppm-www.apgea.army.mil
FARMING/NON-HODGKIN'S LYMPHOMA
A relationship between the use of high levels of pesticides
20 years ago and non-Hodgkin's lymphoma has been suggested in a National Cancer
Institute study. DDT, carbofuran, and chloraben use were positively associated
with non-Hodgkin's lymphoma while atrazine, cyanizine, glyphosate, lindane,
and nicotine were associated with the development of small cell lymphocytic
lymphoma. (American Journal of Epidemiology 122(3)535, 1985)
IU Research Links Dieting Habits With Risk For
Estrogen-Responsive Cancers
This study demonstrated that when beta-HCH, a compound in lindane, is released
from fat it has a larger effect on the uterine tissue than did DDT-- a
now-banned insecticide-- but DDT did have some estrogenic effect on uterine
tissue.
Beta-HCH is less fat soluble and therefore more water soluble than DDT so it can
get into the blood and travel to the breast, uterus and liver.
In a December 1996 study in Cancer Research, Dr. Bigsby and his colleagues
showed that beta-HCH and DDT stimulated the growth of breast tumor tissue that
was grafted into mice. Since the epithelial cells of the breast are surrounded
by fat cells the effect of a diet-induced loss of fat may be of special concern
with regard to the release of these xenoestrogens.
http://www.medicine.indiana.edu/news_releases/archive_97/dietingandcancer2.htm
Evidence for Carcinogenicity
Classification of carcinogenicity: 1) evidence in humans:
inadequate; Overall summary evaluation of carcinogenic risk to humans is Group
2B: The agent is possibly carcinogenic to humans. /From table/ /Hexachlorocyclohexanes/
[IARC.
Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man.
Geneva: World Health Organization, International Agency for Research on
Cancer,1972-PRESENT. (Multivolume work).,p. S7 64 (1987)]**PEER REVIEWED**
CLASSIFICATION: B2; probable human carcinogen. BASIS FOR
CLASSIFICATION: Assays in four strains of mice have yielded positive
carcinogenicity results for t-HCH administered in diet. HUMAN CARCINOGENICITY
DATA: Inadequate.
[U.S.
Environmental Protection Agency's Integrated Risk Information System (IRIS) on
technical Hexachlorocyclohexane (t-HCH) (608-73-1) Available from: http://www.epa.gov/ngispgm3/iris
on the Substance File List as of March 15, 2000]**PEER REVIEWED**
TOXNET
HEXACHLOROCYCLOHEXANE
(TECHNICAL HCH AND LINDANE)
Hexacyclohexanes are possibly carcinogenic to humans
(Group 2B).
Group 2B: The agent (mixture) is possibly
carcinogenic to humans.
The exposure circumstance entails exposures that are possibly carcinogenic to
humans.
This category is used for agents, mixtures and exposure
circumstances for which there is limited evidence of carcinogenicity in
humans and less than sufficient evidence of carcinogenicity in
experimental animals. It may also be used when there is inadequate evidence
of carcinogenicity in humans but there is sufficient evidence of
carcinogenicity in experimental animals. In some instances, an agent, mixture or
exposure circumstance for which there is inadequate evidence of
carcinogenicity in humans but limited evidence of carcinogenicity in
experimental animals together with supporting evidence from other relevant data
may be placed in this group. Supplement 7: (1987) (p. 220)
Carcinogenicity
rating on chemicals
IARC
AND NTP CARCINOGEN LIST
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