IN PATIENTS, ATTEMPTS TO TREAT BLEPHARITIS & DEMODEX FALLICULORUM OF LIDS ... HAVE CAUSED EXCESSIVE IRRITATION OF EYES, EVEN WHEN CONCN AS LOW AS 0.1% WERE EMPLOYED IN COMBINATION WITH TOPICAL CORTICOSTEROIDS. ... KWELL OINTMENT CONTAINING 1% LINDANE HAS CAUSED CONJUNCTIVITIS WHEN APPLIED TO EYELASHES. AS DUST, LINDANE ... CAUSED IRRITATION OF EYES & RESPIRATORY PASSAGES IN PARTICULARLY SENSITIVE INDIVIDUALS.
[Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 561]**PEER REVIEWED**

THE DRUG IS HIGHLY TOXIC & MUST BE USED WITH CARE. IT IS IRRITATING TO MUCOUS MEMBRANES & SHOULD NOT BE PERMITTED TO COME IN CONTACT WITH THE EYES. THE PRESENCE OF SECONDARY INFECTION DOES NOT INTERFERE WITH ITS USE.
[American Hospital Formulary Service. Volumes I and II. Washington, DC: American Society of Hospital Pharmacists, to 1984.,p. 84:04]**PEER REVIEWED**

Allergic contact dermatitis has not been documented, but irritant contact dermatitis has been reported when ... applied excessively, too frequently, or for extended periods.
[American Medical Association, AMA Department of Drugs. AMA Drug Evaluations. 5th ed. Chicago: American Medical Association, 1983. 1850]**PEER REVIEWED**

LINDANE APPLICATIONS SHOULD NOT BE ADMIN TO PREGNANT WOMEN, SMALL INFANTS OR INDIVIDUALS WITH EXTENSIVELY EXCORIATED SKIN. PATIENTS OF ANY AGE SHOULD NOT RECEIVE MORE THAN 2 COURSES OF TREATMENT WITHIN A MONTH, & EACH COURSE SHOULD INCL ONLY 2 APPLICATIONS AT LEAST 1 WK APART. IT SHOULD NOT BE APPLIED AFTER A HOT BATH. CREAM OR LOTION SHOULD BE REMOVED BY BATHING AFTER 6 HR. IT SHOULD BE THOROUGHLY WASHED OFF SCROTAL SKIN. INFANTS MUST BE PREVENTED FROM LICKING CREAM OR LOTION FROM SKIN. FOR INFANTS & PRESCHOOLERS ALTERNATIVE DRUGS INCL CROTAMITON, BENZYL BENZOATE & SULFUR.
[TELCH J, JARVIS DA; CAN MED ASSOC J 126 (6): 662-3 (1982)]**PEER REVIEWED**

Lindane should be used with caution in pregnant or nursing women since the drug can be absorbed systemically following topical application. The Centers for Disease Control (CDC) currently states that lindane is not recommended for use in pregnant or nursing women.
[American Society of Hospital Pharmacists. American Hospital Formulary Service - Drug Information 86. Bethesda, MD: American Society of Hospital Pharmacists,1986 (Plus Supplements, 1986). 1766]**PEER REVIEWED**

Resistance to lindane may develop in strains of Pediculus capitis /causative organism of scabies/.
[American Society of Hospital Pharmacists. American Hospital Formulary Service - Drug Information 86. Bethesda, MD: American Society of Hospital Pharmacists,1986 (Plus Supplements, 1986). 1765]**PEER REVIEWED**
HSDB