Parkinson's Disease
| Title: ORGANOCHLORINE INSECTICIDES IN SUBSTANTIA NIGRA IN PARKINSON'S
DISEASE |
| Author(s): F.M. Corrigan; C.L. Wienburg; R.F. Shore; S.E. Daniel; D.
Mann |
| Source: Journal
of Toxicology and Environmental Health Part A Volume:
59 Number: 4 Page: 229 -- 234 |
| DOI: 10.1080/009841000156907 |
| Publisher: Taylor and Francis Ltd |
| Abstract: The concentrations of organochlorine (OC) compounds in the
substantia nigra (SN) were compared in Parkinson's disease (PD) with
concentrations in brain from cortical Lewy body dementia (CLBD), Alzheimer's
disease (AD), and nondemented nonparkinsonian controls (CON). The levels of the
gamma isomer of hexachlorocyclohexane (g HCH, lindane) were significantly higher
in PD tissues (mean +/- SD: 0.56 +/- 0.434 mug/g lipid) than in the other three
groups (CLBD 0.052 +/- 0.101 mug/g lipid; AD none detected; CON 0.125 +/- 0.195;
all differences from PD significant at p < .05, Mann-Whitney U-test).
Dieldrin (HEOD) was higher in PD brain than in AD or control brain, while
1,1'-(2,2-dichloroethenyl diene)-bis(4-chlorobenzene) (p,p-DDE) and total
Aroclor-matched polychlorinated biphenyls (matched PCBs) were only higher in PD
substantia nigra when these concentrations were compared with those of CLBD.
These findings are not inconsistent with the hypothesis derived from
epidemiological work and animal studies that organochlorine insecticides produce
a direct toxic action on the dopaminergic tracts of the substantia nigra and may
contribute to the development of PD in those rendered susceptible by virtue of
cytochrome P-450 polymorphism, excessive exposure, or other factors. |
ORGANOCHLORINE
INSECTICIDES IN SUBSTANTIA NIGRA IN PARKINSON'S DISEASE
This is more of the saga of Physics and PD.
It is presented here in the interest of research.
University Times VOLUME 27 NUMBER 16
Copyright (c) , University of Pittsburgh
And among the building materials only three substances were found with links
to Parkinson's disease. They were manganese, chlordane and lindane.
Manganese has been shown to cause Parkinson's disease in miners who inhale
its dust. However, the manganese found in Allen Hall was 1,000 times below the
levels considered safe by the federal government and was sealed within the
building's bricks.
Chlordane and lindane were among the ingredients of once common pesticides
banned 10-15 years ago. The amounts of both chlordane and lindane found at Allen
Hall were very tiny and only on the outside of the building.
"The bottom line to all of our technical investigation was that we
really could not find anything that scientifically or medically was of any
concern or that we could link in anyway to the Parkinson's cluster," said
Tollerud.
http://www.parkinsons-information-exchange-network-online |