| AUTHOR: |
|
Trivedi NP, Rawal UM |
| TITLE: |
|
Hepatoprotective and antioxidant property of Andrographis paniculata (Nees)
in BHC induced liver damage in mice. |
| SOURCE: |
|
Indian J Exp Biol; 39(1):41-6 2001 UI: 21247932 |
| ABSTRACT: |
|
Andrographis paniculata (AP) treatment prevents BHC induced increase in the
activities of enzymes y-Glutamyl transpeptidase, glutathione-S-transferase and
lipid peroxidation. The activities of antioxidant enzymes like superoxide
dismutase, catalase, glutathione peroxidase and the levels of glutathione were
decreased following BHC effect. Administration of AP showed protective effects
in the activity of superoxide dismutase, catalase, glutathione peroxidase,
glutathione reductase as well the level of glutathione. The activity of lipid
peroxidase was also decreased. The result indicate antioxidant and
hepatoprotective action of A. paniculata. |
| MESH TERMS: |
|
Animal |
|
|
Antioxidants/*Pharmacology |
|
|
Hepatitis, Toxic/Enzymology/Metabolism/*Prevention and Control |
|
|
Lindane/*Toxicity |
|
|
Lipid Peroxidation/Drug Effects |
|
|
Liver/*Drug Effects |
|
|
Liver Neoplasms, Experimental/Chemically Induced/Enzymology/Metabolism/*Prevention
and Control |
|
|
Male |
|
|
Mice |
|
|
Plant Extracts/*Pharmacology |
|
|
Plants, Medicinal/*Chemistry |
| LANGUAGE: |
|
ENG |
| PUBLICATION TYPE: |
|
JOURNAL ARTICLE |
| TITLE ABBREVIATION: |
|
Indian J Exp Biol |
| YEAR: |
|
2001 |
| ADDRESS: |
|
Zoology Department, Gujarat University, Ahmedabad 380009, India. |
| ENTRY MONTH: |
|
200105 |
| CAS NO.: |
|
0 (Antioxidants) |
|
|
0 (Plant Extracts) |
|
|
58-89-9 (Lindane) |